设为首页  |  加入收藏
 首页 | 学院概况 | 师资队伍 | 党建工作 | 人才培养 | 学术科研 | 合作办学 | 学团工作 | 招生就业 | 产业新闻 
站内搜索:
 
  师资队伍  
 
 教师风采 
 硕士生导师 
 泰山学者 
 
  教师风采
当前位置: 首页 > 师资队伍 > 教师风采 > 正文
 
生物制药教研室
2017年06月20日 14:25      浏览:

姓名

于鹏飞

性别

出生年月

1982.09

最高学历

研究生

最高学位及专业

博士 微生物与生化药学

最后毕业学校

沈阳药科大学

职称

讲师

所在教研室

生物制药

邮箱

hazacar.2012@gmail.com

研究方向

抗肿瘤药物的筛选及分子机制的研究

个人学习及工作经历

1. 20067月毕业于泰山医学院药学专业,获得医学学士学位

2. 20097月毕业于烟台大学药物化学专业,获医学硕士学位

3. 20157月毕业于沈阳药科大学微生物与生化药学专业,获理学博士学位

4. 20097月至20167月就职于绿叶制药集团研发中心从事新药药理毒理研究

5. 20167月至今 就职于滨州医学院药学院从事生物制药专业的教学及科研工作

5年主持(或参与)的教学科研项目情况

主持NSK-01105抑制HER2高表达的乳腺癌细胞增殖及其机制研究,滨州医学院人才引进启动基金 

取得教学、科研成果

(发表论文、专利、成果获奖等情况)

1. Yu P, Ye L, Wang H, Du G, Zhang J, Zuo Y, Zhang J, Tian J. NSK-01105 inhibits proliferation and induces apoptosis of prostate cancer cells by blocking the Raf/MEK/ERK and PI3K/Akt/mTOR signal pathways. Tumour Biol. 2015, 36(3), 2143-2153. (IF,2.926)

2. Yu P, Ye L, Wang H, Du G, Zhang J, Zhang J, Tian J. NSK-01105, a Novel Sorafenib Derivative, Inhibits Human Prostate Tumor Growth via Suppression of VEGFR2/EGFR-  Mediated Angiogenesis. Plos One. 2014 Dec 31;9(12):e115041. (IF,3.057)

3. Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang G. Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology. 2009, 59 (3), 219-229. (IF,1.864)

4. Wang S, Liu Q, Zhang Y, Liu K, Yu P(并列第一作者), Liu K, Luan J, Duan H, Lu Z, Wang F, Wu E, Yagasaki K, Zhang G. Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Molecular Cancer. 2009, 8:81. (IF,5.888)

5. Zhang Y, Zhang H, Yu P(并列第一作者), Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009, 59 (3):191-200. (IF,1.864)

其他(学术兼职、指导研究生等情况)

 

 

 

姓名

张静

性别

出生年月

1983.01

最高学历

研究生

最高学位及专业

博士 生物化学与分子生物学

最后毕业学校

中国海洋大学

职称

副教授

所在教研室

生物制药教研室

邮箱

jing0126@163.com

研究方向

1. 生物材料的改性及应用研究

2. 纳米材料的制备及应用研究

个人学习及工作经历

1. 2001/09-2005/06,中国海洋大学,生物科学专业,学士

2. 2005/09-2010/06,中国海洋大学,生物化学与分子生物学专业,博士(硕博连读)

3. 2010/07-2013/11,滨州医学院,药学院,讲师

4. 2013/12-至今,滨州医学院,药学院,副教授

5. 2015/09-2016/09,中国药科大学,药学院,访问学者

5年主持(或参与)的教学科研项目情况

主持科研项目:

1. 山东省自然基金项目:壳聚糖修饰的多层纳米脂质体协同给药体系的构建及对乳腺癌的透皮治疗(ZR2013EMQ008

2. 山东省教育厅高校科技计划项目:疏水改性壳聚糖自组装纳米胶囊的制备及对紫杉醇的负载(J11LF88

主持教学项目:

1. 滨州医学院教学改革与研究项目:以能力培养为核心的《生物制药学》教学改革研究(JYKT201240

2. 滨州医学院教学改革与研究项目:LBL 联合PBL 在《生物制药学》教学中的应用(JYKT201621

取得教学、科研成果

(发表论文、专利、成果获奖等情况)

1. Jing Zhang, Yujie Sun, Baocheng Tian, Keke Li, Lele Wang, Yan Liang, Jingtian Han*, Multifunctional mesoporous silica nanoparticles modified withtumor-shedable hyaluronic acid as carriers for doxorubicin, Colloids and Surfaces B: Biointerfaces, 2016, 144: 293–302.SCI,影响因子3.902

2. Jing Zhang, Xi Guang Chen*, Lu Huang, Jing Tian Han, Xiao Fan Zhang, Self-assembled polymeric nanoparticles based on oleic acid-grafted chitosan oligosaccharide: biocompatibility, protein adsorption and cellular uptake, Journal of materials science: materials in medicine, 2012, 23(7): 1775-1783.SCI,影响因子2.379

3. Jing Zhang*, Jian Han, Xiuli Zhang, Jing Jiang, Maolei Xu, Daolai Zhang, Jingtian Han*, Polymeric nanoparticles based on chitooligosaccharide as drug carriers for co-delivery of all-trans-retinoic acid and paclitaxel, Carbohydrate Polymers, 2015, 129: 25-34.SCI,影响因子4.219

4. Yujie Sun, Jing Zhang(共同第一作者), Jian Han, Baocheng Tian, Yanan Shi, Yuanyuan Ding, Lele Wang, Jingtian Han*, Galactose-Containing Polymer-DOX Conjugates for Targeting Drug Delivery, AAPS PharmSciTech, 2017, 18(3):749-758.SCI,影响因子1.954

其他(学术兼职、指导研究生等情况)

硕士生导师,指导研究生1

 

 

 

姓名

张秀丽

性别

出生年月

1974.11

最高学历

研究生

最高学位及专业

博士 生物化工

最后毕业学校

大连理工大学

职称

副教授

所在教研室

生物制药

邮箱

Zhangxiuli2008@163.com

研究方向

1. 神经药物和神经毒理学

2. 睡眠呼吸疾病机制和药物研究

个人学习及工作经历

学习经历

1/2016-至今  访问学者 Biological Sciences Department, the University of Chicago, 芝加哥, 美国

12/2014-12/2015  访问学者  Department of Pharmacology, Rush University Medical   芝加哥,美国

08/2011-06/2012   访问学者 北京大学,生命科学学院

2005.9-2008.9,博士研究生,大连理工大学环境与生命学院,生物化工专业,导师:安利佳教授。

2003.9-2005.9,硕士研究生,大连理工大学环境与生命学院,生物化工专业,导师:安利佳教授。

1993.9-1997.7,本科生,大连理工大学化工学院,化学工程专业,获得学士学位。

工作经历

2008.9-至今      滨州医学院药学院    教师    从事教学科研工作。

1997.7–2003.7      齐鲁石化工程公司    工程师  从事技术整改工作。

 

5年主持(或参与)的教学科研项目情况

1. 国家自然基金项目:

(1) 六溴环十二烷通过星形胶质细胞介导神经发育毒性的机制研究(81273037);国家自然基金;2013.1-2013.12;第1位,结题。16

(2) 原儿茶酸在帕金森病中的神经保护作用及对PHOX-ROSTLR4信号通路的调控机制研究(81102828);国家自然基金;2012.1-2014.12;第1位,结题。22

2. 山东省自然基金项目:

(1) Jarid1d/Jarid1c基因在铅暴露引发神经发育毒性中的作用及其表观遗传学调控机制研究;山东省自然基金(2015ZRB14548);2015.8-2018.8;第1位,在研。15

(2) 原儿茶酸在抑制PHOX-ROS/TLR4信号通路及保护多巴胺神经元退化中的作用研究(ZR2011HM011);山东省自然基金;2011.7-2014.7;第1位,结题。8

3. 横向课题:

甜梦口服液调解失眠大鼠脑内神经递质的研究(荣昌制药合作项目)

 

取得教学、科研成果

(发表论文、专利、成果获奖等情况)

1. SCI论文:

(1)Ying-Jie Peng, Xiuli Zhang, Anna Gridina, Irina Chupikova, David L McCormick, Robert Thomas, Thomas E Scammell, Gene Kim, Chirag Vasavda, Jayasri Nanduri, Ganesh K. Kumar, Gregg L. Semenza, Solomon H Snyder, NANDURI R Prabhakar. Gasotransmitters in Sleep Apnea: Complementary Roles of CO and H2S. Proc Natl Acad Sci U S A. 2017, 114(6):1413-1418. (SCI收录, 9.423 )

(2) Xiuli Zhang, Xiuhua Wang, Jing Zhang, Xiaohong Pan, Jing jiang, Yachen Li. Effects of Taurine on Alterations of Neurobehavior and Neurodevelopment Key Proteins Expression in Infant Rats by Exposure to Hexabromocyclododecane. Advances in Experimental Medicine and Biology, 2017, Accepted (SCI收录, 1.953)

(3) Yachen li, Shuangyue li, Xizhe Xie, Hang Xiu, Xiaohui liu, Jing Shao, Xiuli zhang*. Neuroprotection by Taurine on HBCD-induced Apoptosis in PC12 Cells. Advances in Experimental Medicine and Biology, 2017, Accepted. (通讯作者,SCI收录, 1.953)

(4) Lu liu, Lianying Guo, Xizhe Xie, Ning fan, Yan li, Yachen li, Xiuli zhang*. Taurine Alleviate Hexabromocyclododecane-induced Cytotoxicity in PC12 Cells via Inhibiting Oxidative Stress.  Advances in Experimental Medicine and Biology, 2017, Accepted (通讯作者,SCI收录, 1.953)

(5) Xinyun Su, Chunhua Wang, Xiuhua Wang, Fang Han, Changjun Lv, Xiuli Zhang*. Sweet Dream Liquid Chinese Medicine Ameliorates Learning and Memory Deficit in a Rat Model of Paradoxical Sleep Deprivation through the ERK/CREB Signaling Pathway. J Med Food. 2016, 19(5):472-80. (通讯作者,SCI收录,1.844

(6) Xue Yin, Xiuli Zhang*, Changjun Lv, Chunli Li, Yan Yu, Xiaozhi Wang, Fang Han. Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia. Scientific Reports, 2015, 5:14507. doi: 10.1038/srep14507. (通讯作者SCI, 5.578)

(7) Yingzhen Xu, Ruyi Zhang, Chunli Li, Xue Yin, Changjun Lv, Yaoqi Wang, Wenxiang Zhao, Xiuli Zhang*. Dexmedetomidine Attenuates Acute Lung Injury Induced by Lipopolysaccharide in Mouse through Inhibition of MAPK Pathway. Fundamental & clinical pharmacology, 201529(5):462-71. (通讯作者SCI, 2.121)

(8) Zhang Xiuli*, Li Chunli, Li Jun, Xu Yingzhen, Guan Shui, Zhao Mingshan. Protective Effects of Protocatechuic Acid on Acute Lung Injury Induced by Lipopolysaccharide in Mice via p38MAPK and NF-κB Signal Pathways. International Immunopharmacology, 2015, 26(1):229-36. (通讯作者SCI, 2.472)

(9)  Wang Zhuo, Pan Xiaohong, Wang Dan, Sun Hongliu, Han Fang, Lv Changjun, Zhang XiuLi. Protective effecs of Protocatechuic acid on retinal ganglion cells from oxidative damage induced by H2O2. Neurological Research. 2015, 37(2):159-66. (通讯作者SCI, 1.449)

(10) Wang Zhuo, Wang Dan, Li Yan, Zhang Xiuli. Protective effects of Verapamil against H2O2-induced apoptosis in human lens epithelial cell. Biomolecules & Therapeutics. 2014, 22(6):553-7.. (通讯作者SCI, 1.727)

(11) Zhang XiuLi, Li Chunli, Yin Xue, Su Xinyun, Yu Dehong. A Comparison Study on Microwave-assisted Extraction of Catalpol from Rehmannia glutinosa Libosch with Conventional Methods. Advanced materials research,2014,1033-1034:329-336. (EI收录)

(12) Zhang Xiuli, Jin Changzhu, Li Yachen,, Guan Shui, Han Fang, Zhang Shuping. Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by D-galactose. Food and Chemical Toxicology, 2013, 58: 50–55. (SCI收录, 3.01)

(13) Pan Xiaohong, Zhang Xiuli, Sun Hongliu, Zhang Jinjin, Yan Miaomiao, Zhang Huaibin. Autophagy Inhibition Promotes 5-Fluorouraci-Induced Apoptosis by Stimulating ROS Formation in Human Non-Small Cell Lung Cancer A549 Cells. PLoS One. 2013;8(2):e56679

(共同第一作者,SCI收录, 4.092)

(14) Guan Shui, Zhang Xiu-li, Lin Xiao-Min, Liu Tian-Qing, Ma Xue-Hu, Cui Zhan-Feng. Chitosan/gelatin porous scaffolds containing hyaluronic acid and heparan sulfate for neural tissue engineering. Journal of Biomaterials Science, Polymer Edition, 2013;24(8):999-1014 (SCI收录, 1.7)

(15) Zhang Xiu-Li, Shi Gui-fang, Liu Xiu-zhen, An Li-Jia, Guan Shui. Antiaging effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice. Cell Biochemistry & Function, 2011, 29: 342–347. (SCI收录, 1.651)

(16) Wang Yue-si, Zhang Xiuli, Zhang Yan, Xu Hui, Fang Guang-li. Expression and localization of IL-18 in the hypothalamic–pituitary–ovarian axis of non-pregnant, pregnant, and abortive rats.Journal of Reproductive Immunology 2011,92,45– 53.(通讯作者,SCI收录,2.203

(17) Guan Shui, Zhang Xiu-Li, Ge Dan, Liu Tian-Qing, Ma Xue-Hu, Cui Zhan-Feng. Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells. European journal of pharmacology, 2011 30;670(2-3):471-478. (SCI收录,2.736)

(18) Zhang Xiu-Li, Liu Wei-Dong, Niu Xin-Hua, An Li-Jia. Systemic administration of catalpol prevents D-galactose induced mitochondrial dysfunction in mice. Neuroscience Letters, 2010, 473:224–228. (SCI收录,2.200)

(19) Gao Wei, Bao Yong-Ming, Liu Yang, Zhang Xiu-Li, Wang Jing-Yun, An Li-Jia. Characterization of thermo-stable endoinulinase from a new strain Bacillus sp T7. Applied Biochemistry and Biotechnology, 2009, 157(3): 498-506. (SCI收录,1.04)

(20) Zhang Ai-Hong, Hao Shuang, Bi Jing, Bao Yong-Ming, Zhang Xiu-Li, An Li-Jia, Jiang Bo. Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation. Experimental and Toxicologic Pathology, 2009, 61(5): 461-469. (SCI收录,1.226)

(21) Zhang Xiu-Li, Zhang Ai-HongJiang Bo, Bao Yong-Ming, Wang Jing-Yun, An Li-Jia. Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa. Phytomedicine2008, 15,484-490. (SCI收录,2.330)

(22) Zhang Xiu-Li, An Li-Jia, Bao Yong-Ming, Wang Jing-Yun, Jiang Bo. D-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol. Food and Chemical Toxicology, 2008, 46(8):2888-2894. (SCI收录,3.01)

(23) Jiang Bo, Zhang Huan, Bi Jing, Zhang Xiu-Li. Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity. Neurological Research, 2008, 30(6):639-44. (SCI, 1.634)

(24) Jing Bi, Jiang Bo, Liu Jian-Hui, Lei Chen, Zhang Xiu-Li, An Li-Jia. Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures. Neuroscience Letters, 2008, 442(3): 224-227. (SCI, 2.200)

(25) Li Zhi-Bo, Wang Jing-Yun, Jiang Bo, Zhang Xiu-Li, An Li-Jia. Benzobijuglone, a novel cytotoxic compound from Juglans mandshurica, induced apoptosis in HeLa cervical cancer cells. Phytomedicine2007, 14(12): 846-852. (SCI, 2.330) 

(26) Zhang Xiu-Li, Jiang Bo, Li Zhi-Bo, Hao Shuang, An Li-Jia. Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Pharmacology, Biochemical and Behavior. 2007, 88, 64-72. (SCI, 2.751)

2. 中文核心期刊论文:

(1) 李春丽,徐洋,姜静,王春华,张树平,张秀丽. 甜梦口服液对睡眠剥夺大鼠学习记忆、炎症因子及神经递质的影响. 中药药理与临床,2015,2 (通讯作者核心)

(2) 尹雪, 苏新云, 王秀华, 苏佳丽, 廉艳, 张秀丽. 原儿茶酸对帕金森病模型小鼠中脑和纹状体D2DRiNOSTH表达的影响中草药2015,6 (通讯作者,核心)

(3) 徐颖臻, 刘爽, 李亚晨, 李岚, 于燕, 赵文香, 张秀丽. 银杏叶提取物对帕金森病大鼠多巴胺神经元的保护作用中药药理与临床,2015,2

(4) 李颖, 张秀丽, 汪卓. 人参皂苷Rb1H2O2损伤RGC-5细胞的保护作用及机制探讨. 山东医药, 2014, 4754):5-8.(通讯作者,核心)

(5) 李君, 赵铭山, 张秀丽, 李岩, 韩冰. 原儿茶酸对脂多糖诱导的急性肺损伤小鼠的保护作用. 现代生物医学进展. 20141414):2646-2649.

(6) 翟红莉, 王辉, 张秀丽, 蔡彩虹, 梅文莉, 戴好富. 高良姜提取物对PC12细胞的神经保护作用. 热带生物学报, 2014, 1

(7) 宫健伟, 叶蕾, 张秀丽, 樊巧玲.  地黄饮子对脑缺血再灌注模型大鼠血清、脑组织SOD,CATGSH-PxMDA的影响. 中国实验方剂学杂志, 2013, 19(14)247-250.

(8) 张秀丽,于德红,刘德胜,刘秀珍,张树平. 梓醇对鱼藤酮致小鼠中脑和纹状体线粒体酶活性改变的改善作用. 中国药理学和毒理学杂志,201226(5),618-623(核心,CA收录)

(9) 张秀丽,于德红,刘德胜,张静. 正交试验优化梓醇的微波辅助提取工艺.现代生物医学进展2012,12,3487-3490. (核心,CA收录)

(10) 张秀丽,刘秀珍. 梓醇对D-半乳糖致亚急性衰老小鼠学习记忆及脑中相关抗氧化酶活性的影响. 中国生化药物杂志,201132:103-106. (核心,CA收录)

(11) 张秀丽,李亚晨,牛新华,张树平.原儿茶酸对帕金森模型鼠脑组织抗氧化能力的影响.现代生物医学进展, 2011,11:3248-3251(核心,CA收录)

(12) 张秀丽, 王静云, 姜波, 安利佳. 大孔吸附树脂分离纯化地黄中梓醇工艺的研究.中国生物工程杂志. 2008,28(1): 65-69. (核心)

其他(学术兼职、指导研究生等情况)

指导研究生5

 

 

 

网站声明:转载或引用本文,须注明本文出处,违者必究

 

国家中医药管理局 | 山东省中医药管理局 | 沈阳药科大学 | 渤海制药集团 | 山东国际生物科技园 | 荣昌制药 | 烟台荣昌生物工程公司
Copyright © 2000-2011 by DCC 滨州医学院药学院版权所有
烟台校区:山东省烟台市莱山区观海路346号 邮编:264003 滨州校区:山东省滨州市滨城区黄河三路522号 邮编:256603